Neuronal Death in Amyotrophic Lateral Sclerosis Is Apoptosis

Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis

Wide-spread fasciculations are a characteristic feature in amyotrophic lateral sclerosis (ALS), suggesting motor axonal hyperexcitability. Previous excitability studies have shown increased nodal persistent sodium conductances and decreased potassium currents in motor axons of ALS patients, both of the changes inducing hyperexcitability. Altered axonal excitability potentially contributes to mo...

Programmed cell death in amyotrophic lateral sclerosis.

Metallothionein-III prevents neuronal death and prolongs life span in amyotrophic lateral sclerosis model mice.

Defect of metallothionein-III (MT-III) has been reported to be a contributor to the progression of amyotrophic lateral sclerosis (ALS). We explored the expression and effects of MT-III on the motor neurons of spinal cords of ALS model mice (G93A Cu/Zn superoxide dismutase (SOD-1) mutant-transgenic (Tg) mice) using a retrograde viral delivery system. Once-weekly injection of the adenovirus encod...

Propagation: prion-like mechanisms can explain spreading of motor neuronal death in amyotrophic lateral sclerosis?

Journal of Neurology Neurosurgery & Psychiatry (ISSN No: 0022-3050) is published monthly by BMJ Publishing Group and distributed in the USA by Mercury International Ltd. as mailing agent. Periodicals postage paid at Rahway, NJ. POSTMASTER: send address changes to Journal of Neurology Neurosurgery & Psychiatry, Mercury International Ltd, 365 Blair Road, Avenel, NJ, 07001, USA. Editorial commenta...

Amyotrophic Lateral Sclerosis in a Patient with Behçet’s ‎Disease

Behçet’s ‎disease is a multisystem vasculitis. Its neurological involvement mostly includes parenchymal and non-parenchymal central nervous system manifestations. Peripheral nervous system presentations are rare. A 32-yr-old male patient who fulfilled the international study group criteria for Behçet’s disease, referred to our center with walking difficulty and repeated falling downs. Neurologi...